Materials Scientist (Formulation Development)
Listed pay for MS-level Formulation / Compounding roles on Crosslinked center on $119k (11 with a salary).
Lead formulation development of room-temperature-stable solid formulations containing live bacterial actives.
Worth knowing
Why it is interesting. Own end-to-end formulation of a novel solid-state live biotherapeutic, from bench to manufacturing transfer.
Might not be for you. No visa sponsorship; requires full on-site presence in Bay Area.
Core polymer roleformulating body-safe solids, semisolids, or complex multicomponent systems (gels, waxes, structured solids), and cross-linking systems
- Seniority
- Mid-level
- Work
- On-site
- Type
- Full-time
- Degree
- MS
- Experience
- 3+ yrs
- Industry
- Biotechnology
- Role
- Formulation / Compounding
- Visa
- No sponsorship
Role details
Materials Scientist (Formulation Development)
The Opportunity (Full-time, Bay Area)
We're seeking a hands-on materials scientist to lead formulation development for a room-temperature-stable solid/semisolid product containing live bacterial actives. The core technical challenge: engineering a cold-formed solid-state formulation that keeps live cultures viable and stable through manufacturing, shipping, and shelf life.
You will own the experimental work end-to-end: designing and executing experiments to develop formulations, establishing processing methods, and rigorously measuring performance. You will collaborate closely with our microbiology team to understand our actives’ sensitivity to temperature, humidity, and excipients. You will also work closely with manufacturing operations to develop process and formulation specifications and guide technology transfer, ensuring formulations meet requirements for stability, manufacturability, raw-material availability, and cost.
You'll operate as an independent scientist within a lean, highly skilled team, with real ownership over your experimental direction and results.
Required Qualifications
✔️
Advanced technical training
— PhD, or MS/M.Eng with 3+ years of hands-on formulation/process R&D, in materials science, chemistry, chemical engineering, bioengineering, polymer science, or a related field.
✔️
Solid-state formulation expertise
— hands-on experience formulating body-safe solids, semisolids, or complex multicomponent systems (gels, waxes, structured solids), and cross-linking systems (e.g., ionic, covalent, or physical/associative gelation).
✔️
Quantitative characterization
— experience designing assays to characterize material properties, iteratively optimize composition against material behavior, and troubleshoot failures (sweating/syneresis, melting/softening, clumping, cracking), including rheometry, texture analysis, DSC, water activity and moisture sorption, and accelerated shelf-life/thermal-cycling testing.
✔️
Hands-on prototyping and equipment ownership
— experience and eagerness to design and execute bench-scale experiments, from sourcing and setting up unfamiliar lab and processing equipment to running and troubleshooting autonomously.
✔️
Rigorous lab documentation
— track experimental data, formulation SOPs, and sample materials with precision and reproducible documentation..
✔️
Full on-site availability
— based in or willing to relocate to the Bay Area.
✔️ Authorized to work in the U.S.
— visa sponsorship is not available for this role.
Highly Desirable Experience
✔️
Stabilization science for labile biologicals
— experience with eutectics/eutectogels, vitrification/glassy-state material, or anhydrous systems, and an understanding of water activity, moisture control, and temporal (shelf-life) stability.
✔️
Microbiology stability
— direct experience stabilizing live bacteria or other labile biologicals in room-temperature formulations, including maintaining CFU viability through processing, drying, and storage, and characterizing desiccation tolerance, thermal cycling response, and rehydration kinetics.
✔️
Process development and pilot production
— experience translating lab-scale formulations into reproducible batches at scale, and prior research on how mixing, shear, cooling/forming rates, and other unit operations affect crystallization behavior, phase separation, and CFU survival at scale-up.
✔️
Encapsulation or powder processing
— experience with microencapsulation, spray-drying, lyophilization, or granulation for live biologicals.
✔️
Equipment sourcing and lab setup
— vendor evaluation and hands-on operation of both processing equipment (controlled-rate mixers, extruders, molding/forming lines) and bench analytical instruments such as a rheometers, texture analyzers, DSC, water activity meters, and environmental/stability chambers.
Transparent Compensation
✔️
Base salary
— $140,000 annual.
✔️
Equity
— meaningful equity package as a core component of total compensation.
✔️
Benefits
— comprehensive health, dental, and vision insurance.
✔️
Retirement
— 401(k) plan with 6% employer match.
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